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Workshop on hybrid and multiscale modelling in cell and cell population biology
Paris, France, 16-18 March 2015
Presentation
Multi-scale models in cell biology are actively developed in order to describe physiological processes. There are various approaches to multi-scale modelling and numerous applications. Cell populations in multi-scale models can be described by discrete or continuous methods. Among them are cellular automata, lattice Boltzmann methods and various particle methods. These approaches allow a detailed description of cell behaviour, cell-cell interactions and other aspects of complex biological media. On the other hand, such individual-based models are applicable for a relatively small number of cells and they do not admit analytical investigation. Continuous models are represented by ordinary and partial differential equations for cell concentrations. In particular, these include reaction-diffusion equations, which take into account random motion of cells, and their birth and death. Navier-Stokes equations and Darcy equations describe convective motion of the medium. Other models include physiologically structured integro-differential equations, in particular to describe nonlocal non-spatial evolution phenomena in cell populations, such as carcinogenesis and drug resistance in cancer.
Multi-scale models involve intracellular and extracellular regulations of biological cells. Intracellular regulation is particularly important because it determines cell fate, that is the choice between its proliferation (self-renewal), [de-]differentiation or senescence/apoptosis. Cell fate can be described by ordinary differential equations for intracellular concentrations of determinant proteins, by Boolean approaches or by probabilistic methods at the cell population level when a small number of molecules participate in this regulation and when their concentrations cannot be considered. Extracellular regulation can be effectuated by various local mechanisms in a given tissue (growth factors, cytokines) or by means of global control from other organs and tissues through endocrine signalling. Extracellular substances diffuse in the tissue and influence intracellular regulation of cells. Distribution of these substances can be described by reaction-diffusion equations when space is relevant to describe tissue evolution (which is not necessarily the general case).
Cell populations, intracellular and extracellular regulations can also be modelled using hybrid discrete-continuous methods. These describe cells as individual objects with various lattice or off-lattice methods, intracellular regulatory networks with ordinary differential equations and extracellular substances with partial differential equations. Such models are developed in order to study differentiation in cell lineages, in particular for haematopoiesis and for other physiological processes. They can take into account cell motion, division, death, interactions with other cells and with the surrounding medium. Transition from hybrid to continuous models can be justified for some model examples. Multi-scale models can manifest interesting nonlinear dynamics, different from those obtained with classical reaction-diffusion equations. This proposed workshop aims at bringing together teams working in multiscale modelling and hybrid models in cell biology, involving mathematicians, physicists and biologists. It will conclude the ANR “Bimod” research project (V. Volpert, J. Clairambault, P. Magal).
Organisers
Jean Clairambault, Laboratoire Jacques-Louis Lions, UPMC, CNRS & INRIA
Vitaly Volpert, Institut Camille Jordan, Université Lyon 1
Participants
Mostafa Adimy, INRIA Dracula, Lyon
Loïc Barbarroux, INRIA Dracula, Lyon
Sébastien Benzekry, INRIA MC2, Bordeaux
Anass Bouchnita, Lyon
Helen Byrne, Mathematical Institute, University of Oxford
Mark Chaplain, Division of Mathematics, University of Dundee
Arnaud Chauvière, Université de Grenoble
Jean Clairambault, INRIA Mamba
Fabien Crauste, INRIA Dracula, Lyon
Marcello Delitala, Politecnico di Torino, Turin
Jacques Demongeot, Université de Grenoble
Andreas Deutsch, Technische Universität Dresden
Dirk Drasdo, INRIA Mamba
Florence Hubert, Institut de Mathématiques de Marseille
Tommaso Lorenzi, INRIA Mamba
Anna Marciniak-Czochra, Universität Heidelberg
Roeland Merks, CWI, Amsterdam
Roberto Natalini, IAC-CNR, Rome
Victor Pérez García, Universidad Castilla -La Mancha, Ciudad Realde préférence
Luigi Preziosi, Politecnico di Torino, Turin
Angélique Stephanou, TIMC-IMAG, Grenoble
Zuzanna Szymańska, Université de Varsovie
Alen Tosenberger, Bruxelles
Laura de Vargas Roditi, ETH Zürich
Vitaly Volpert, INRIA Dracula, Lyon
Romain Yvinec, INRA Tours
Jorge Zubelli, IMPA
Sponsors
Series
- AMCSE - International Conference on Applied Mathematics, Computational Science and Systems Engineering
- CMES - International Conference of Computational Methods in Engineering Science
- ICMSA - IMT-GT International Conference on Mathematics, Statistics and Their Applications
- ITA Annual International Conference on Information Technology and Applications
- Workshop on hybrid and multiscale modelling in cell and cell population biology
- ZkwE - Computer Applications in Electrical Engineering
II International Conference of Computational Methods in Engineering Science
II International Conference of Computational Methods in Engineering Science
Presentation
II International Conference of Computational Methods in Engineering Science CMES ’17 takes place in Lublin, 23-25 November 2017 at Lublin University of Technology, Poland. The main objective of CMES’17 conference is development of engineering sciences, numerical and experimental techniques, broaden experience and good practices by representatives of the scientific community and industry. Conference allows exchange of knowledge between different research domestic and foreign centres representing various fields of engineering science and technology.
The organizers of the conference are:
- Department of Thermodynamics, Fluid Mechanics and Aircraft Propulsion (Mechanical Engineering Faculty, Lublin University of Technology)
- Department of Machine Engineering Fundamentals and Mechatronics (Mechanical Engineering Faculty, Lublin University of Technology)
- Department of Materials Engineering (Mechanical Engineering Faculty, Lublin University of Technology)
- Institute of Computer Science (Faculty of Electrical Engineering and Computer Science, Lublin University of Technology)
- Department of Organisation of Enterprise (Faculty of Management, Lublin University of Technology)
- Self-Government of Doctoral Students (Lublin University of Technology)
- Polish Association for Knowledge Promotion
Topics
- Analysis of engineering processes
- Application of computer programs in technology
- Computer aided design/manufacturing (CAD/CAM)
- Computational and artificial intelligence
- Computational fluid dynamics (CFD)
- Computational methods in electrical engineering
- Computer methods in applied physics
- Computer simulations of processes and phenomena
- Evaluation of technological processes
- Exploitation and machine building
- Finite element method (FEM)
- Material properties and structure research methods
- Probability, statistics and quality control
- Production engineering
- and related topics
Organizing committee
Monika Kulisz, Chairman
Mirosław Szala, Vice-chairman
Marcin Badurowicz
Magdalena Borys
Wojciech Cel
Zbigniew Czyż
Katarzyna Falkowicz
Justyna Kujawska
Tytus Tulwin
Scientific committee
Maksym Bondarenko, Cherkasy State Technological University, Ukraine
František Brumerčík, University of Žilina, Slovakia
Jacek Czarnigowski, Lublin University of Technology, Poland
Dariusz Czerwiński, Lublin University of Technology, Poland
Hubert Dębski, Lublin University of Technology, Poland
Agata Dudek, Częstochowa University of Technology, Poland
Gabriel Fedorko, Technical University of Košice, Slovakia
Jakub Gajewski, Lublin University of Technology, Poland
Arkadiusz Gola, Lublin University of Technology, Poland
María Hallo, Escuela Politécnica Nacional, Ecuador
Tadeusz Hejwowski, Lublin University of Technology, Poland
Józef Jonak, Lublin University of Technology, Poland
Jerzy Józwik, Lublin University of Technology, Poland
Yevgenia Katayeva, Cherkasy State Technological University, Ukraine
Ján Král, Technical University of Košice, Slovakia
Jacek Kęsik, Lublin University of Technology, Poland
Grzegorz Kozieł, Lublin University of Technology, Poland
Andrzej Kwiecień, Silesian University of Technology, Poland
Jerzy Lipski, Lublin University of Technology, Poland
Grzegorz Litak, AGH University of Science and Technology, Poland
Paweł Lonkwic, The State School of Higher Education in Chełm, Poland
Sergio Luján-Mora, University of Alicante, Spain
Marek Miłosz, Lublin University of Technology, Poland
Vieroslav Molnár, Technical University of Košice, Slovakia
Jerzy Montusiewicz, Lublin University of Technology, Poland
Rosa Navarette, Escuela Politécnica Nacional, Ecuador
Ali Özer, Cumhuriyet University, Turkey
Małgorzata Plechawska-Wójcik, Lublin University of Technology, Poland
Anna Rudawska, Lublin University of Technology, Poland
Sandra Sánchez, Escuela Politécnica Nacional, Ecuador
Mirosław Skrzewski, Silesian University of Technology, Poland
Maria Skublewska-Paszkowska, Lublin University of Technology, Poland
Ondrej Stopka, Institute of Technology and Business in České Budějovice, Czech Republic
Barbara Surowska, Lublin University of Technology, Poland
Branislav Šarkan, University of Žilina, Slovakia
Jakub Szabelski, Lublin University of Technology, Poland
Yassine Tabaa, Abdelmalek Essaâdi University, Marocco
Ualsher Tukeyev, alFarabi Kazakh National University, Kazakhstan
Yuriy Tryus, Cherkasy State Technological University, Ukraine
David Vališ, University of Defence, Czech Republic
Ján Vrábel, University of Žilina, Slovakia
Mariusz Walczak, Lublin University of Technology, Poland
Mirosław Wendeker, Lublin University of Technology, Poland
Tadeusz Wieczorek, Silesian University of Technology, Poland
Tomasz Zientarski, Lublin University of Technology, Poland
Honorary patronage
