ITM Web Conf.
Volume 7, 20163rd Annual International Conference on Information Technology and Applications (ITA 2016)
|Number of page(s)
|Session 9: Computer Science and its Applications
|21 November 2016
Genetic Circuit for the Early Warning of Lung Cancer using iBioSim
1 School of Electronic and Information Engineering, Beihang University, Beijing, 100191, China
2 Honors College of Beihang University, Beihang University, Beijing, 100191, China
a Corresponding author: firstname.lastname@example.org
With the development of molecular biology and gene-engineering technology, gene diagnosis has been an emerging approach for modern life sciences. Biological marker, recognized as the hot topic in the molecular and gene fields, has important values in early diagnosis, malignant tumour stage, treatment and therapeutic efficacy evaluation. The design of markers detection genetic circuit system for lung cancer is presented as a new method to provide basis for early warning and therapy. The system consists of three single-marker detection circuits and an integration circuit. The single-marker detection circuit provides an instantaneous low level when target marker’s concentration reaches the threshold. The integration circuit uses gene and gate to complete the output data fusion from single-marker detection circuit through logic operations to finish the combined detection. All the structure is modelled and analyzed by iBioSim through the biochemical reactions of different gene circuits. The experimental result indicates that the whole lung cancer detection system can realize joint detection of tumor markers with good stability and sensitivity.
© Owned by the authors, published by EDP Sciences, 2016
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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