ITM Web Conf.
Volume 31, 2020International Conference “Mathematical Modelling in Biomedicine” 2019
|Number of page(s)||7|
|Published online||09 March 2020|
Shape effects in biological adhesion of ellipsoidal cells
1 Department of Mathematics, Faculty of Physics, M.V.Lomonosov Moscow State University, Moscow 119991, Russia
2 Department of Biophysics, Faculty of Physics, M.V.Lomonosov Moscow State University, Moscow 119991, Russia
3 Interdisciplinary Research Center Mathematical Modelling in Biomedicine, RUDN University, 117198 Moscow, Russia
Blood platelet adhesion is crucial for arterial thrombosis and hemostasis. The attachment of platelets to the injuries takes place under the action of high hydrodynamic forces and relies on the formation of breakable ligand-receptor bonds between the cell and the adhesive substrate. In this work we study how the geometrical effects may change the adhesive forces that stick platelets to the wounds. The mathematical model shows that oblate cells with high aspect ratio are more favourable for thrombus growth.
© The Authors, published by EDP Sciences, 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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