| Issue |
ITM Web of Conferences
Volume 4, 2015
Workshop on Mathematics for Life Sciences (WMLS 2014)
|
|
|---|---|---|
| Article Number | 01002 | |
| Number of page(s) | 7 | |
| DOI | https://doi.org/10.1051/itmconf/20150401002 | |
| Published online | 07 May 2015 | |
Initiation of erythropoiesis by BFU-E cells
1 Laboratoire de Biométrie et Biologie Evolutive, UMR 5558 CNRS, University Lyon 1, 69622 Villeurbanne, France
2 Institut Camille Jordan, UMR 5208 CNRS, University Lyon 1, 69622 Villeurbanne, France
3 Vanderbilt University Medical Center, Nashville, TN, USA
a e-mail: volpert@math.univ-lyon1.fr
Erythropoiesis is the process of red blood cell production in the bone marrow. Terminal stages of human erythropoiesis occur in multicellular structures called erythroblastic islands (EBIs). EBIs contain up to several dozen erythroid cells of varying maturities organized around a central macrophage. Immature erythroid cells, burst forming units (BFU-E) circulate in blood and home to bone marrow, where they can have limited but random movement. When BFU-Es approach a macrophage, they divide producing colony forming units-erythroid (CFU-E), which are the next stage of erythroid differentiation. CFU-Es and their immediate progeny, proerythroblasts, can self-renew, differentiate into more mature cells or die by apoptosis. The BFU-E, CFU-E, and the subsequent erythroblast stages provide normal functioning of erythropoiesis. In this work we develop a hybrid discrete-continuous model in order to describe normal erythropoiesis in the bone marrow. Cells are represented as individual objects that move, divide, differentiate, die and interact with each other. We show how BFU-E cells initiate EBIs.
© Owned by the authors, published by EDP Sciences, 2015
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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