| Issue |
ITM Web of Conferences
Volume 5, 2015
Workshop on Multiscale and Hybrid Modelling in Cell and Cell Population Biology
|
|
|---|---|---|
| Article Number | 00008 | |
| Number of page(s) | 4 | |
| DOI | https://doi.org/10.1051/itmconf/20150500008 | |
| Published online | 11 December 2015 | |
Normal erythropoiesis and development of multiple myeloma
1 Laboratoire de Biométrie et Biologie Evolutive (LBBE), University Lyon 1 69622 Villeurbanne, France
2 Institut Camille Jordan (ICJ), University Lyon 1 69622 Villeurbanne, France
3 Vanderbilt University Medical Center, Nashville, TN, USA
a e-mail: anass.bouchnita@univ-lyon1.fr
We develop a hybrid multi-scale model of normal and pathological erythropoiesis, the process of red blood cell production in the bone marrow. Cells are described by a soft sphere model. They can move, divide and die by apoptosis. Their fate is determined by intracellular proteins, by extracellular substances and surrounding cells. We apply this model to describe normal function of erythropoiesis and the development of multiple myeloma in the bone marrow. It is a malignant disease characterized by proliferation of mutated plasma cells which form multiple tumors in the bone marrow. They disrupt erythroblastic islands by direct mechanical contact and due to apoptotic cytokines produced by myeloma cells. The development of the disease leads to decrease of red blood cell production and to anemia.
© Owned by the authors, published by EDP Sciences, 2015
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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