ITM Web of Conferences
Volume 5, 2015Workshop on Multiscale and Hybrid Modelling in Cell and Cell Population Biology
|Number of page(s)||4|
|Published online||11 December 2015|
Emergence of cytotoxic resistance in cancer cell populations*
From individual-level mechanisms to population-level consequences
1 Centre de Mathématiques et de Leurs Applications, ENS Cachan, CNRS, Cachan 94230 Cedex, France & Sorbonne Universités, UPMC Univ Paris 06, CNRS, INRIA, UMR 7598, Laboratoire Jacques-Louis Lions, Équipe MAMBA, 4, place Jussieu 75005, Paris, France
2 School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney NSW 2052, Australia
3 Sorbonne Universités, UPMC Univ Paris 06, CNRS, INRIA, UMR 7598, Laboratoire Jacques-Louis Lions, Équipe MAMBA, 4, place Jussieu 75005, Paris, France
4 Sorbonne Universités, UPMC Univ Paris 06, F-75005, Paris, France & INSERM, UMR_S 938, Laboratory of “Cancer Biology and Therapeutics”, F-75012, Paris, France
* T. Lorenzi and R.H. Chisholm contributed equally to this project
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We formulate an individual-based model and an integro-differential model of phenotypic evolution, under cytotoxic drugs, in a cancer cell population structured by the expression levels of survival-potential and proliferation-potential. We apply these models to a recently studied experimental system. Our results suggest that mechanisms based on fundamental laws of biology can reversibly push an actively-proliferating, and drug-sensitive, cell population to transition into a weakly-proliferative and drug-tolerant state, which will eventually facilitate the emergence of more potent, proliferating and drug-tolerant cells.
© Owned by the authors, published by EDP Sciences, 2015
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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