| Issue |
ITM Web of Conferences
Volume 5, 2015
Workshop on Multiscale and Hybrid Modelling in Cell and Cell Population Biology
|
|
|---|---|---|
| Article Number | 00003 | |
| Number of page(s) | 4 | |
| DOI | https://doi.org/10.1051/itmconf/20150500003 | |
| Published online | 11 December 2015 | |
Hybrid model of clot formation in flow
1 Unité de Chronobiologie Théorique, Faculté des Sciences, Université Libre de Bruxelles (ULB), Campus Plaine, CP 231, Brussels B-1050, Belgium
2 Institute of Mechanical Engineering Problems, 199178 Saint Petersburg, Russia
3 Institut Camille Jordan, UMR 5208 CNRS, University Lyon 169622 Villeurbanne, France
4 INRIA Team Dracula, INRIA Antenne Lyon la Doua, 69603 Villeurbanne, France
a e-mail: alen.tosenberger@ulb.ac.be
The process of blood coagulation and clot formation in vivo is not yet completely understood. One of the main questions related to haemostasis is why the clot stops growing in normal conditions before it completely obstructs the flow in the vessel, whereas, in pathologic cases, it can continue to grow, often with fatal consequences. Hence, revealing the mechanisms by which the clot grows and stops growing in the flow remains of great importance. In order to study this topic we have developed a hybrid DPD-PDE method where Dissipative Particle Dynamics (DPD) is used to model plasma flow and platelets, while the protein regulatory network is described by a system of partial differential equations. The model describes the interaction between blood flow, platelet aggregation and plasma coagulation. As a result of modelling we propose a new mechanism of clot growth and growth arrest in flow. The developed model and its parts can be used as a base to modelling of different physiological phenomena related to cell-cell interactions and blood flows.
© Owned by the authors, published by EDP Sciences, 2015
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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