| Issue |
ITM Web of Conferences
Volume 5, 2015
Workshop on Multiscale and Hybrid Modelling in Cell and Cell Population Biology
|
|
|---|---|---|
| Article Number | 00004 | |
| Number of page(s) | 4 | |
| DOI | https://doi.org/10.1051/itmconf/20150500004 | |
| Published online | 11 December 2015 | |
Relevance of Cell-ECM Interactions: From a Biological Perspective to the Mathematical Modeling
Dipartimento di Scienze Matematiche, Politecnico di Torino
a e-mail: luigi.preziosi@polito.it
b e-mail: marcosci1@alice.it
Cell migration across fibre networks and micro-channel structures has been widely demonstrated to be strongly influenced by the interactions between moving individuals and the surrounding extracellular matrix as well as by the mechanical properties of cell nucleus. In this respect, our work will be devoted to describe several mathematical models, which deal either with cell adhesion mechanics or with suitable analysis of the role played in cell movement by nucleus stiffness. In particular, the presented approaches span from discrete individual-based methods to continuous models and provide useful insights into selected determinant underlying cell migration within two-and three-dimensional matrix environments.
© Owned by the authors, published by EDP Sciences, 2015
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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