| Issue |
ITM Web of Conferences
Volume 5, 2015
Workshop on Multiscale and Hybrid Modelling in Cell and Cell Population Biology
|
|
|---|---|---|
| Article Number | 00011 | |
| Number of page(s) | 4 | |
| DOI | https://doi.org/10.1051/itmconf/20150500011 | |
| Published online | 11 December 2015 | |
Mathematical modeling of the microtubule dynamic instability: a new approch of GTP-tubulin hydrolysis
1 Aix-Marseille University, CNRS, Centrale Marseille, I2M UMR 7373, Marseille cedex 13, France
2 Aix-Marseille University, INSERM, CRO2, UMR_S 911, France
a e-mail: florence.hubert@univ-amu.fr
Microtubules, components of the cytosqueleton, play an important role in cell division, cell migration and thus in the cancer proccess through dynamic instability. Therefore they are an important target for anti-cancer treatment. Proper modelling of dynamic instability is a crucial tool to understand the mechanism of action of microtubule targeting agents. In this paper, we propose a new concept for GTP-tubulin hydrolysis which allow the model to accurately reproduce microtubule dynamics observed in vitro or in cells. This approach will be more appropriate to take study the effects of drugs.
© Owned by the authors, published by EDP Sciences, 2015
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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